Blender uses AVX2 in the render engine cycles.
OpenSSL uses AVX- and AVX2-optimized cryptographic functions since version 1.0.2.[33]. This support is also present in various clones and forks, like LibreSSL
Prime95/MPrime, the software used for GIMPS, started using the AVX instructions since version 27.x.
dav1d AV1 decoder can use AVX2 on supported CPUs.[34]
dnetc, the software used by distributed.net, has an AVX2 core available for its RC5 project and will soon release one for its OGR-28 project.
Einstein@Home uses AVX in some of their distributed applications that search for gravitational waves.[35]
RPCS3, an open source PlayStation 3 emulator, uses AVX2 and AVX-512 instructions to emulate PS3 games.
Network Device Interface, an IP video/audio protocol developed by NewTek for live broadcast production, uses AVX and AVX2 for increased performance.
Tensorflow since version 1.6 requires CPU supporting at least AVX.[36]
Xenia requires AVX instruction set in order to run.
x264, x265 and VTM[disambiguation needed] video encoders can use AVX2 or AVX-512 to speed up encoding.
Various CPU-based cryptocurrency miners (like pooler's cpuminer for Bitcoin and Litecoin) use AVX and AVX2 for various cryptography-related routines, including SHA-256 and scrypt.
libsodium uses AVX in the implementation of scalar multiplication for Curve25519 and Ed25519 algorithms, AVX2 for BLAKE2b, Salsa20, ChaCha20, and AVX2 and AVX-512 in implementation of Argon2 algorithm.
libvpx open source reference implementation of VP8/VP9 encoder/decoder, uses AVX2 or AVX-512 when available.
FFTW can utilize AVX, AVX2 and AVX-512 when available.
LLVMpipe, a software OpenGL renderer in Mesa using Gallium and LLVM infrastructure, uses AVX2 when available.
glibc uses AVX2 (with FMA) for optimized implementation (i.e. expf, sinf, powf, atanf, atan2f) of various mathematical functions in libc.
Linux kernel can use AVX or AVX2, together with AES-NI as optimized implementation of AES-GCM cryptographic algorithm.
Linux kernel uses AVX or AVX2 when available, in optimized implementation of multiple other cryptographic ciphers: Camellia, CAST5, CAST6, Serpent, Twofish, MORUS-1280, and other primitives: Poly1305, SHA-1, SHA-256, SHA-512, ChaCha20.
POCL, a portable Computing Language, that provides implementation of OpenCL, makes use of AVX, AVX2 and AVX512 when possible.
.NET Core and .NET Framework can utilize AVX, AVX2 through the generic System.Numerics.Vectors namespace.
.NET Core, starting from version 2.1 and more extensively after version 3.0 can directly use all AVX, AVX2 intrinsics through the System.Runtime.Intrinsics.X86 namespace.
EmEditor 19.0 and above uses AVX-2 to speed up processing.