Das bedeutet, man hat ein Plateau bzw Vorteil nur die ersten 4 bis 6 Wochen durch creatin oder versteh ich das falsch?
naja - je nachdem, ob man (schnell) geladen hat. Hat man dies hat man nach L. 4-6 Wochen Vollgaseffekt und dann 4-6 Wochen einen abfallenden Effekt, bis er sich negiert. Ich schaue gerade, wie gegenläufige Meinungen sich begründen.
Edit: Washout dauert länger als 30 Tage http://www.ncbi.nlm.nih.gov/pubmed/14971966
In der Petrischale wird das Transporterprotein runterreguliert http://www.ncbi.nlm.nih.gov/pubmed/9746337
Zusf.: Die Konzentration bestimmter Kreatinwerte nimmt ab, es wird spekuliert, ob es mit der down-regulation von Transporterproteinen zu tun hat.Subsequent switching to a daily maintenance dose of 2 g [ day−", as recently suggested by an expert committee during the American College of Sports Medicine Roundtable meeting [11], for a total period of 6 weeks resulted in a significant reduction in muscle CrP and total creatine content to values that were not significantly different from baseline values (Table 2). Only the muscle free
creatine concentration remained elevated at the level obtained following creatine loading (Table 2). Our present findings, for reasons that are not clear, are in contrast with those of Hultman et al. [5], who concluded that a maintenance dose of 2 g [ day−" was enough to maintain both muscle CrP and total creatine content at the levels obtained after creatine loading. One of the
reasons to explain the gradual decline in muscle CrP and total creatine content, as seen in our subjects, could be the down-regulation of muscle creatine transporters [33,34]
Gegenstudie von Hultman: http://www.ncbi.nlm.nih.gov/pubmed/8828669
ABER
Zusf.: Die Kraftzuwächse blieben - konnten sich aber nicht überall von der Placebogruppe abheben.Interestingly, high-intensity exercise performance remained enhanced after 6 weeks of continued creatinensupplementation within the C group, despite the fact that muscle CrP content had returned to baseline values. This may suggest that the increase in muscle free and total
creatine remaining in the C group after 6 weeks (Table 2) results in an increased CrP rephosphorylation rate during the active rest period in between sprints, as previously
suggested by Greenhaff et al. [2]. Another potential explanation is an increase in the muscle mass that is used in the HIT test (see below). However, the increased performance in the HIT test after the 6 week supplementation period was not significantly different from the P group. We conclude that both short-term and prolonged creatine supplementation (using a maintenance dose of 2 g [ day−", following the initial loading phase), improved performance capacity during repeated high-intensity sprints on a cycle ergometer.
http://www.clinsciusa.org/cs/104/0153/1040153.pdf
Zuletzt bearbeitet: